Protocols
Study schedules referenced. This hub organizes the topic into a starting point, core reading, and deeper reference material so mobile readers and search systems can understand the page pathway quickly.
Get oriented first
Begin with the plain-language framing before reading narrower claims or legal and safety details.
Read the central articles
Use the core set to understand the topic before moving into edge cases and supporting references.
Education, not instruction
This section does not provide medical, dosing, sourcing, purchasing, or legal advice.
The common microdosing protocols — Fadiman 1/3/1, the Stamets Stack, every-other-day, the Nightcap — and why they're documented conventions, not validated regimens.
How microdosing calendars differ — Fadiman 1/3/1, every-other-day, the Nightcap, personalized — and their trade-offs. Comparing conventions, not ranking by effect.
Finding the Dose: The Sub-Perceptual Target, Titration, and Why Weight Is a Poor ProxyWhat 'finding your dose' means: the sub-perceptual target, how titration works, why mushroom weight is a poor proxy — and why it isn't a dose recommendation.
The Fadiman Protocol (1/3/1): What It Is and What Actually Documents ItThe Fadiman 1/3/1 microdosing schedule — dose day, two rest days, repeat — its tolerance rationale, and why it's the best-documented protocol but not a proven one.
The Stamets Stack — psilocybin plus Lion's Mane and niacin: its preclinical rationale, the unsupported niacin claim, and the one study that found no added benefit.
Tolerance and Cycling: Why Protocols Build in Rest Days — and What That Reasoning Does and Doesn't EstablishWhy microdosing schedules build in rest days: the tolerance rationale from full-dose pharmacology — and why that plausibility isn't demonstrated microdose benefit.
Tracking and Evaluation: Useful for Your Own Decisions, Powerless to Prove CauseWhy a microdosing log helps your own decisions but can't prove the substance caused the change — self-report on a known dose day is where expectation operates.